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| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2020 | MEDICINES CO /DE | MDCO | 0 | -1,448,662 | 0 | -123,049,000 | |
| 12/31/2019 | MEDICINES CO /DE | MDCO | 1,448,662 | -1,552,700 | 123,049,000 | -27,019,000 | $84.94 |
| 09/30/2019 | MEDICINES CO /DE | MDCO | 3,001,362 | -452,657 | 150,068,000 | 24,100,000 | $50.00 |
| 06/30/2019 | MEDICINES CO /DE | MDCO | 3,454,019 | -363,525 | 125,968,000 | 19,268,000 | $36.47 |
| 03/31/2019 | MEDICINES CO /DE | MDCO | 3,817,544 | 520,728 | 106,700,000 | 43,599,000 | $27.95 |
| 12/31/2018 | MEDICINES CO /DE | MDCO | 3,296,816 | 1,417,229 | 63,101,000 | 6,883,000 | $19.14 |
| 09/30/2018 | MEDICINES CO /DE | MDCO | 1,879,587 | -224,652 | 56,218,000 | -21,008,000 | $29.91 |
| 06/30/2018 | MEDICINES CO /DE | MDCO | 2,104,239 | -54,694 | 77,226,000 | 6,111,000 | $36.70 |
| 03/31/2018 | MEDICINES CO /DE | MDCO | 2,158,933 | -11,282 | 71,115,000 | 11,781,000 | $32.94 |
| 12/31/2017 | MEDICINES CO /DE | MDCO | 2,170,215 | 408,177 | 59,334,000 | -5,932,000 | $27.34 |
| 09/30/2017 | MEDICINES CO /DE | MDCO | 1,762,038 | -1,915,708 | 65,266,000 | -74,525,000 | $37.04 |
| 06/30/2017 | MEDICINES CO /DE | MDCO | 3,677,746 | 655,065 | 139,791,000 | -8,018,000 | $38.01 |
| 03/31/2017 | MEDICINES CO /DE | MDCO | 3,022,681 | 2,074,261 | 147,809,000 | 115,620,000 | $48.90 |
| 12/31/2016 | MEDICINES CO /DE | MDCO | 948,420 | 948,420 | 32,189,000 | 32,189,000 | $33.94 |
| 03/31/2012 | MEDICINES CO /DE | MDCO | 0 | -24,621 | 0 | -459,000 | |
| 12/31/2011 | MEDICINES CO /DE | MDCO | 24,621 | -17,990 | 459,000 | -175,000 | $18.64 |
| 09/30/2011 | MEDICINES CO /DE | MDCO | 27,641 | 450 | 411,000 | -38,000 | $14.87 |
| 06/30/2011 | MEDICINES CO /DE | MDCO | 27,191 | -1,060 | 449,000 | -11,000 | $16.51 |
| 03/31/2011 | MEDICINES CO /DE | MDCO | 28,251 | 0 | 460,000 | 61,000 | $16.28 |
| 12/31/2010 | MEDICINES CO /DE | MDCO | 28,251 | 8,000 | 399,000 | 111,000 | $14.12 |
| 09/30/2010 | MEDICINES CO /DE | MDCO | 20,251 | 11,570 | 288,000 | 222,000 | $14.22 |
| 06/30/2010 | MEDICINES CO /DE | MDCO | 8,681 | 8,681 | 66,000 | 66,000 | $7.60 |
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